Genomes 4 Paperback 4

T. A.Brown

Genomes 4 has been completely revised and updated. It is a thoroughly modern textbook about genomes and how they are investigated. As with Genomes 3 techniques come first then genome anatomies followed by genome function and finally genome evolution. The genomes of all types of organism are covered: viruses bacteria fungi plants and animals including humans and other hominids. Genome sequencing and assembly methods have been thoroughly revised including a survey of four genome projects: human Neanderthal giant panda and barley. Coverage of genome annotation emphasizes genomewide RNA mapping with CRISPRCas 9 and GWAS methods of determining gene function covered. The knowledge gained from these techniques forms the basis of the three chapters that describe the three main types of genomes: eukaryotic prokaryotic (including eukaryotic organelles) and viral (including mobile genetic elements). Coverage of genome expression and replication is truly genomic concentrating on the genomewide implications of DNA packaging epigenome modifications DNAbinding proteins noncoding RNAs regulatory genome sequences and proteinprotein interactions. Also included are applications of transcriptome analysis metabolomics and systems biology. The final chapter is on genome evolution focusing on the evolution of the epigenome using genomics to study human evolution and using population genomics to advance plant breeding. Established methods of molecular biology are included if they are still relevant today and there is always an explanation as to why the method is still important. Each chapter has a set of shortanswer questions indepth problems and annotated further reading. There is also an extensive glossary. Genomes 4 is the ideal text for upper level courses focused on genomes and genomics.

9780815345084

English

Garland Science

524

Terry Brown is professor of Biomolecular Archaeology at Manchester University. As well as writing the previous editions of Genomes, he is the author of Introduction to Genetics: A Molecular Approach (Garland 2011) and 5 editions of DNA Cloning & Analysis (Wiley Blackwell). He is also an experienced teacher of genetics.

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