Gene Regulation, Epigenetics And Hormone Signaling Hardcover

Mandal, Subhrangsu S.

The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

9783527322817

English

Wiley-VCH Verlag GmbH

23 Oct 2017

668

Subhrangsu S. Mandal, editor for the proposed book, has broad-based experience in field of human gene regulation biochemistry, steroid hormone signalling, and epigenetics and in chemistry. Dr. Mandal was originally trained as an organic chemist and during PhD, he researched on bioinorganic/biophysical chemistry. Later on during his postdoc he has completely changed his research focus towards understanding the biochemistry of human gene regulation and chromatin modification. His current research is aimed towards understanding the epigenetic mechanism of human gene expression and steroid hormone signalling associated with cardiovascular diseases and cancer. His research is published in high impact journals such as Oncogene, British Journal of Cancer, Biochemistry, Journal of Molecular Biology, Journal of Molecular Endocrinology, FEBS Journal, Proceedings of National Academy of Sciences, Genes and Development, Molecular Cell, and Cell. He has also one US patent on novel anticancer drugs. His research is funded by National Institute of Health, National Science Foundation, American Heart Association and others. Consequently, he is familiar with the process of manuscript preparation for publication. More details of his professional experience are included in the CV below. CV: Subhrangsu S. Mandal is currently Associate Professor at the Department of Chemistry and Biochemistry, at The University of Texas at Arlington, Texas. He received his PhD degree from the Indian Institute of Science, Bangalore, where he worked on chemical nucleases and cationic liposome-mediated gene delivery in the laboratory of Professor S. Bhattacharya. He joined the laboratory of Professor Linda J. Reha-Krantz as an Alberta Heritage Foundation for Medical Research (AHFMR) postdoctoral fellow in the University of Alberta, Canada. He later moved to the laboratory of Professor Danny Reinberg to research on eukaryotic transcription and gene regulation in human at the University of Medicine and Dentistry of New Jersey (UMDNJ)/Howard Hughes Medical Institute (HHMI). Prof. Mandal began his independent career at University of Texas at Arlington in 2005. Specifically he is investigating the function of Mixed Lineage Leukemia (MLL) family of histone methyl-transferases in gene activation, estrogen signalling, and tumorigenesis. In parallel, Mandal laboratory is also developing novel gene targeted cancer therapy using mice models.

Subhrangsu S. Mandal