Missing Data In Clinical Studies Hardcover

Geert Molenberghs

Missing Data in Clinical Studies provides a comprehensive account of the problems arising when data from clinical and related studies are incomplete, and presents the reader with approaches to effectively address them. The text provides a critique of conventional and simple methods before moving on to discuss more advanced approaches. The authors focus on practical and modeling concepts, providing an extensive set of case studies to illustrate the problems described. * Provides a practical guide to the analysis of clinical trials and related studies with missing data.* Examines the problems caused by missing data, enabling a complete understanding of how to overcome them.* Presents conventional, simple methods to tackle these problems, before addressing more advanced approaches, including sensitivity analysis, and the MAR missingness mechanism.* Illustrated throughout with real-life case studies and worked examples from clinical trials.* Details the use and implementation of the necessary statistical software, primarily SAS. Missing Data in Clinical Studies has been developed through a series of courses and lectures. Its practical approach will appeal to applied statisticians and biomedical researchers, in particular those in the biopharmaceutical industry, medical and public health organisations. Graduate students of biostatistics will also find much of benefit.

0470849819

9780470849811

English

John Wiley & Sons Ltd

4 May 2007

526

Geert Molenberghs and Michael Kenward are the authors of Missing Data in Clinical Studies, published by Wiley.

Michael Kenward

"Missing Data in Clinical Studies does an excellent job of presenting essential ideas on modern concepts and techniques relevant to missing data in clinical studies." (Journal of the American Statistician, December 2008) "Clear, generally accessible and well written, and the content is rich. This text is a highly recommendable addition to the shelves of practicing statisticians." (Journal of Applied Statistics, August 2008) "The authors give key examples in the form of several clinical trials and their analyses using the appropriate remedial techniques." (Journal of Tropical Pediatrics, August 2007)